000			03717cam a2200433Mi 4500
999			_c5270 _d5270
003			OSt
005			20220406084243.0
008			220406b ||||| |||| 00| 0 eng d
020			_a3540099204
040			_cALUPE UNIVERSITY
050			_aRC261 _b.H39 1980
100	1		_aCawley, John C.
245	1	0	_aHairy-Cell Leukaemia / _cby John C. Cawley, Gordon F. Burns, Frank G.J. Hayhoe.
260			_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c1980.
300			_a1 online resource (ix, 123 pages 64 illustrations)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aRecent Results in Cancer Research, Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, _x0080-0015 ; _v72
505	0		_a1 Introduction -- 2 Clinical Aspects -- 2.1 Occurrence -- 2.2 Clinical Features at Presentation -- 2.3 Haematology at Presentation -- 2.4 Other Investigations -- 2.5 Treatment -- 2.6 Clinical and Haematological Progress -- 2.7 Complications and Cause of Death -- 3 Pathology -- 3.1 Bone Marrow -- 3.2 Spleen -- 3.3 Liver -- 3.4 Lymph Nodes -- 4 The Hairy Cell: Cytological Aspects -- 4.1 Cytology -- 4.2 Cytochemistry -- 4.3 Ultrastructure -- 4.4 Cytokinetics -- 4.5 Cytogenetics -- 4.6 Metabolism -- 4.7 Culture -- 5 The Hairy Cell: Immunological Aspects -- 5.1 Transformation and Cytotoxicity Studies -- 5.2 Surface Receptors -- 5.3 Monocytic Features -- 5.4 Immunoglobulin Synthesis and Secretion -- 5.5 Summary of the Immunological Membrane Phenotype of Typical HCs -- 5.6 T-cell Features -- 6 Other Haemic Cells -- 6.1 Granulocytes -- 6.2 Monocytes -- 6.3 Platelets -- 6.4 Lymphocytes -- 7 Diagnosis -- 7.1 Differential Diagnosis -- 7.2 A New Distinct Entity -- 8 Conclusions and Future Trends -- 9 References -- 10 Subject Index.
520			_aHairy-cell leukaemia (HCL) is an established clinicopathological entity typified by a chronic picture of substantial splenomegaly, less frequent hepatomegaly, and only inconspicuous lymphadenopathy. Central to the diagnosis is the pathognomonic hairy cell (HC), a dis tinctive mononuclear cell that circulates in varying numbers and infiltrates a variety of organs, including the bone marrow and spleen. Peripheral pancytopenia is often present, and circulating HCs may be infrequent. HCs are invariably present in the bone marrow; but, per haps because of the extensive fibrosis characteristic of the disease, the marrow is frequently difficult to aspirate, and confirmation of the diagnosis may require histopathological ex amination of biopsy material. The incidence of the disease has been given as 2% ofleukaemias [29, 319] or as approximately 1 % of identifiable lymphomas [230]. Our own experience of collecting cases in the United Kingdom leads us to expect that at any given time one patient with HCL will be attending a clinic serving some 150,000 people.
650		0	_aMedicine.
650		0	_aOncology.
650		2	_aMedicine
650		2	_aMedical Oncology
650		6	_aMédecine.
650		6	_aCancérologie.
650		7	_amedicines (material) _2aat
650		7	_aMedicine. _2fast _0(OCoLC)fst01014893
650		7	_aOncology. _2fast _0(OCoLC)fst01045739
655		0	_aElectronic books.
655		4	_aElectronic books.
700	1		_aBurns, Gordon F.
700	1		_aHayhoe, Frank G. J.
776	1	8	_iPrint version: _z9783642814396
776	1	8	_iOnline version: _aCawley, John C. _tHairy-Cell Leukaemia. _dBerlin, Heidelberg : Springer Berlin Heidelberg, 1980 _w(OCoLC)1296392610
830		0	_aRecent Results in Cancer Research, Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer ; _v72.
942			_2lcc _cBK _nBA